Series episode
| Tim Roth | ... | Dr. Cal Lightman |
| Kelli Williams | ... | Dr. Gillian Foster |
| Brendan Hines | ... | Eli Loker |
| Monica Raymund | ... | Ria Torres |
| Daniel Benzali | ... | Joseph Hollin |
| Megan Dodds | ... | Gail |
| Kirk B.R. Woller | ... | Mike Personick |
| Hayley McFarland | ... | Emily Lightman |
| Sunkrish Bala | ... | Arun Ashraf |
| Anjul Nigam | ... | Shreyas Patel |
| Ajay Mehta | ... | Sulman Lamba / Rohit |
| Michael B. Silver | ... | Personick's Attorney |
| Michelle Joyner | ... | Marlene |
| Mandy June Turpin | ... | Carolyn Hollin |
| Kosha Patel | ... | Kiran Purohit |
| Kristen Ariza | ... | Heidi |
| Dominic Hoffman | ... | SEC Deputy Ian Dawkins |
| Erica Piccininni | ... | Joanna |
| Stacey Moseley | ... | ICU Nurse |
| Naila Azad | ... | Ina Ashraf |
| Seema Lazar | ... | Jaya Ashraf |
| Tejal Shah | ... | Dhara Ashraf |
| Michelle Anne Johnson | ... | Medical Examiner |
| Helen Wassell | ... | Louise |
| Don Tiffany | ... | Paramedic |
| Aliya Astaphan | ... | Cocktail Waitress |
| Joseph Bayard | ... | Lightman Employee |
| Reena Pankaj Shah | ... | Pregnant Hostage |
| Adam Davidson | ... | Direction |
| Dustin Thomason | ... | Script |