Series episode
| Kelsey Grammer | ... | Mayor Tom Kane |
| Connie Nielsen | ... | Meredith Kane |
| Hannah Ware | ... | Emma Kane |
| Jeff Hephner | ... | Ben Zajac |
| Kathleen Robertson | ... | Kitty O'Neill |
| Martin Donovan | ... | Ezra Stone |
| Troy Garity | ... | Sam Miller |
| Francis Guinan | ... | Governor McCall Cullen |
| Rotimi | ... | Darius Morrison |
| Karen Aldridge | ... | Dr. Ella Harris |
| James Vincent Meredith | ... | Alderman Ross |
| Kenny Williams | ... | Himself |
| Tim Decker | ... | Ronnie Moretti |
| Ricardo Gutiérrez | ... | Alderman Lalo Mata |
| Joe Minoso | ... | Moco Ruiz |
| Michael Accardo | ... | Mike Bosovic |
| Roy Anderson | ... | Foreman |
| Ilyssa Fradin | ... | WBBM TV Reporter |
| Doug James | ... | Grey Haired Man |
| Loren Lazerine | ... | Chief Exhumer |
| Maurice Lemon | ... | Alton Morrison |
| Steve Lenz | ... | Phone Monkey / Kane's Aide |
| Eduardo N. Martinez | ... | Ortiz |
| Mia Park | ... | Clinic Volunteer |
| Jessie Perez | ... | Mata's Associate |
| Dale Rivera | ... | Clinic Doctor |
| Juan Gabriel Ruiz | ... | Dilip Singh / Cullen's Aide |
| Joseph Fleetfoot Sada | ... | Chief Billy English |
| Branden Smith | ... | Max Harris |
| Steve Key | ... | Man |
| Sal Velez Jr. | ... | Garza |
| David Windsor | ... | Mata's Associate |
| Cyn Dulay | ... | Newsreporter |
| Elizabeth Reiners | ... | Chicago Alderman |
| Kimberly Azana | ... | Mayor's Office Worker |
| Daniel Boughton | ... | Mayor's Office Employee |
| Anita Nicole Brown | ... | Mayor's Office Employee |
| Gene Bryant | ... | Community Organizer |
| Debbi Burns | ... | Mayor's Staff |
| Roberta Chung | ... | Campaign Worker / Parent |
| Tyler Drew Clayton | ... | Camera man |
| Randall Cropp | ... | College Kid |
| Duke Czlonka | ... | Mayor's Staff |
| Sandy Gulliver | ... | Mayor's Office Employee |
| Thomas Kosik | ... | Staff Member |
| Mino Mackic | ... | Mayor Kane's Commander |
| Thomas McCormick | ... | Exhumer |
| Samuel Meadows | ... | Company Executive |
| José María Mendiola | ... | Mayor's Office Employee |
| Babs Moran | ... | Press |
| Jim Nieciecki | ... | Mayor Kane's Body Guard |
| Russ Panzarella | ... | Campaign Worker |
| Marla Seidell | ... | Alderman |
| Cyril Smith | ... | Campaign Worker |
| Bill Stoneking | ... | Chicago Alderman |
| Chris D. Thomas | ... | Rally Attendee |
| Philip Toca | ... | Haime |
| Robert A. Young | ... | Chicago Police Officer |
| Gus Van Sant | ... | Direction |
| Farhad Safinia | ... | Script |