Series episode
Cast: (20 - show/hide all)
| Jonny Lee Miller | ... | Sherlock Holmes |
| Lucy Liu | ... | Dr. Joan Watson |
| Jon Michael Hill | ... | Detective Marcus Bell |
| Aidan Quinn | ... | Captain Thomas Gregson |
| Christian Campbell | ... | Ezra Kleinfelter |
| Ronald Guttman | ... | Elliot Honeycutt |
| Steve Kazee | ... | Jeff Hines |
| Susan Pourfar | ... | Emily Hankins |
| Laura Osnes | ... | Celia Carroll |
| Peter McRobbie | ... | Milton Van Kirk |
| Adeel Ahmed | ... | Cabbie |
| Anthony Fazio | ... | Delivery Man |
| Chester Jones III | ... | Bike Cop |
| David Hess | ... | Darragh O'Connor |
| Joe Cassidy | ... | Agent 1 |
| Scott Whitehurst | ... | Agent 2 |
| Juan Carlos Infante | ... | CSU Tech |
| Andrew Alberson | ... | Makeup Artist |
| Natalie Dormer | ... | Jamie Moriarty (voice) |
| George Signoriello | ... | Detective |
Crew:
| Michael Pressman | ... | Direction |
| Craig Sweeny | ... | Script |