| Preston Bailey | ... | Cody Bennett (35 episodes) |
| Aimee Garcia | ... | Jamie Batista (34 episodes) |
| Luke Andrew Kruntchev | ... | Harrison Morgan (27 episodes) |
| Erik King | ... | Sgt. James Doakes (25 episodes) |
| Evan George Kruntchev | ... | Harrison Morgan (22 episodes) |
| Dana L. Wilson | ... | Det. Angie Miller (18 episodes) |
| David Ramsey | ... | Anton Briggs (17 episodes) |
| Yvonne Strahovski | ... | Hannah McKay (17 episodes) |
| Keith Carradine | ... | Special Agent Frank Lundy (15 episodes) |
| Bruce Holman | ... | Det. Michael Soderquist (15 episodes) |
| Francisco Viana | ... | Male Detective (13 episodes) |
| Colin Hanks | ... | Travis Marshall (12 episodes) |
| Pablo Soriano | ... | Detective Ramos (12 episodes) |
| Jimmy Smits | ... | Miguel Prado (12 episodes) |
| John Lithgow | ... | Arthur Mitchell (12 episodes) |
| Sean Patrick Flanery | ... | Jacob Elway (12 episodes) |
| Daniel Goldman | ... | Cody Bennett (11 episodes) |
| Valerie Cruz | ... | Sylvia Prado (11 episodes) |
| Courtney Ford | ... | Christine Hill (11 episodes) |
| Billy Brown | ... | Mike Anderson (11 episodes) |
| Josh Cooke | ... | Louis Greene (11 episodes) |
| Jadon Wells | ... | Harrison Morgan (11 episodes) |
| Edward James Olmos | ... | Professor James Gellar (10 episodes) |
| Christian Camargo | ... | Rudy Cooper (10 episodes) |
| Jaime Murray | ... | Lila Tournay (10 episodes) |
| Julia Stiles | ... | Lumen Ann Pierce (10 episodes) |
| Charlotte Rampling | ... | Dr. Evelyn Vogel (10 episodes) |
| Devon Graye | ... | Teenage Dexter (9 episodes) |
| Jason Manuel Olazabal | ... | Ramon Prado (9 episodes) |
| Kristin Dattilo | ... | Detective Barbara Gianna (9 episodes) |
| Rick Peters | ... | Elliot (9 episodes) |
| Katia Winter | ... | Nadia (9 episodes) |
| Ray Stevenson | ... | Isaak Sirko (9 episodes) |
| Andrew Kirsanov | ... | Jurg Yeliashkevych (9 episodes) |
| Mark Pellegrino | ... | Paul Bennett (voice) (8 episodes) |
| Brando Eaton | ... | Jonah Mitchell (8 episodes) |
| April L. Hernandez | ... | Officer Cira Manzon (8 episodes) |
| Jonny Lee Miller | ... | Jordan Chase (voice) (8 episodes) |
| Maria Doyle Kennedy | ... | Sonya (8 episodes) |
| Peter Weller | ... | Stan Liddy (8 episodes) |
